On April 16, 2003, then-municipal mayor Proceso D. Aguillo signed Municipal Ordinance No. 2003-059, “Ordinance Establishing the Pamantasan ng Cabuyao (University of Cabuyao) and Other Purposes,” creating the Pamantasan ng Cabuyao (PnC). The institution began offering classes in business administration, information technology, education, nursing, and midwifery in June 2003.

Before the Pamantasan ng Cabuyao was founded, the Laguna State Polytechnic University (LSPU) had a satellite campus at the Cabuyao National High School. A memorandum of understanding between the mayor of Cabuyao Municipality and the LSPU president served as the basis for the LSPU’s operations. The LSPC-Cabuyao Campus began its operation in 1993 and ended on March 31, 2003.

In the latter half of 2002, faculty and students at LSPC protested against the LSPC president’s leadership. With the support of the majority of students, who were mostly Cabuyeños, the protest was found by the Sangguniang Bayan of Cabuyao to be true and based on facts. It caused the memorandum of agreement to be terminated, and the only option left to the mayor’s administration was to establish Cabuyao Community College.

In light of the anticipated closure of LSPC-Cabuyao, faculty members under the leadership of  Charlemagne Lavina and Frank Parao  aided the mayor’s office and advised them that the Pamantasan ng Lungsod ng Maynila (PLM) is the model school for local colleges. Dr. Benjamin Tayabas, who was president of PLM at the time, helped the town of Cabuyao and personally oversaw the establishment of the institution. He recommended calling it Pamantasan ng Cabuyao. Municipal Ordinance No. 2003-059 was enacted by the Sanguniang Bayan on April 15, 2003. The following day, Mayor Proceso D. Aguillo gave his approval to the same.

Pamantasan ng Cabuyao was personally inaugurated by no less than President Gloria Macapagal Arroyo on June 19, 2003 on the occasion of the 107th birthday of Dr. Jose Rizal and officially started its operations on July 31, 2003, the birthday of its founding mayor.

In 2017, the university received its Commission on Higher Education (CHED) Institutional Recognition, becoming one of the few local colleges and universities (LCUs) to receive such recognition. The university was awarded by the Duterte Administration the right to avail of the FREE COLLEGE EDUCATION or the Universal Access to Quality Tertiary Education (UNIFAST) under the Republic Act 10931 – becoming one of the 76 LCUs in the country to be given such right to free education in 2019.

To date, PnC has been awarded by ALCUCOA with twelve (12) Level 2 and two (2) Level 1 programs. The higher level of accreditation is a testament to the university’s commitment to providing free quality education, especially to its talented marginalized student populace. Today, PnC is one of the few leading local colleges and universities in the Philippines with level 2 accredited programs. The university produced topnotchers in the fields of education, nursing, and engineering.

Forward-looking, PnC envisions itself becoming the premier leading local university in Region IV by further elevating its academic standards, thereby producing value-laden and globally competent graduates and continuously striving for improvement in quality services in instruction, research, and extension.

PnC commits itself to the holistic education of every “Dangal ng Bayan”, thereby producing graduates that bring pride and honor to the nation.